The protective effect of GAC extracts against UVC was found by 20-30%. Our present results suggest that GAC possesses DNA protective ability against H2O2 and UVC. The degree of anti-oxidative damage activity in TK6 cells of GAC extracts is SK95>SMW>SK50.Momordica cochinchinensis (Lour.) fruit of Cucurbitaceae family is indigenous vegetable and fruit to Southeast Asia. It has been generally known as “GAC” whereas in Thailand it is called “Fhuck-khow”. Regarding its richness in anti-oxidants particularly lycopene and beta-carotene, GAC is named "fruit from heaven" and believed to promote longevity, health and vitality. In present study, GAC extracts were prepared from pulp (PU), skin (SK) and seed membrane (SM) by 50%, 95% ethanol and water (W). MTT assay was done in TK6 cells to determine their cytotoxicity property. The non-cytotoxic extracts were further evaluated for the DNA protective activity against H2O2 and UVC using high alkaline (pH >13) comet assay.